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Hordenine HCL

Hordenine HCL

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Descripción

This nootropic is used as an herbal MAO inhibitor to promote focus, concentration and even euphoric feelings. The supplement is also used by bodybuilders, athletes and people trying to lose weight because it can increase metabolism while at the same time decreasing appetite. You will commonly see Hordenine being stacked with phenlyethylamine (PEA) for cognitive enhancement purposes.

 

Verificar:

Hordenine potentiates DMAA. What that means is that it increases the effects of DMAA (not DMAE). DMAA is DiMethylAmylAmine. DMAA is an NRI and Hordenine, in addition to being an MAO-B substrate (a temporary inhibitor), is also a release agent. Hordenine releases norepinephrine, and DMAA keeps it from going outside the synapse. Then, if it does make it outside the synapse, MAO-B is pre-occupied with Hordenine. Thus, Hordenine triples the effect of DMAA, in my opinion.

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Introducción

Hordenine (N,N-dimethyl-4-hydroxyphenylethylamine) is a natural phenethylamine compound that occurs in different plants, notably barley grass.[1] It is structurally related to the amino acid tyramine.[1] Methylation of tyramine creates N-methyltyramine and Hordenine.[1]

This supplement works primarily through the release and protection of norepinephrine, much like other weight-loss supplements.[2] This would explain the benefits of increased metabolism and energy, as well as the decrease in appetite which is apparently a result of slowed digestion.

Users supplement Hordenine for three main effects: fat loss, appetite control, and energy. It is used in many bodybuilding pre-workout stacks for its synergistic effects with PEA.


Beneficios

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Dosage

WHAT is the safety profile on hordenine? Up to 100mg is safe. It will make you high at that dose. I suggest taking it with food and only 50mg at a time.

 

Safety

Hordenine did not affect vole diet intake, weight gain, or rate of mortality. Voles fed hordenine developed kidney lesions and glucose was detected in the urine of 62% of these animals.

 From: http://www.sciencedirect.com/science/article/pii/0300483X8090075X

http://www.ncbi.nlm.nih.gov/pubmed/8582256

 

Cycling

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Hordenine + PEA

Hay que verificar la seguridad de este stack, y la validez del siguiente texto:

While this combination may appear to be good, its supplementation does have a couple of drawbacks. Both Hordenine and PEA are known to have poor bioavailability, which means that some of the effects reported by users may just be placebo. Users who have tried taking an inordinate amount of PEA did report of experiencing a “high” that lasted only for 30 minutes. Hordenine and PEA also have a very short half-life as evidenced by the fact that the effects of this combination dissipates after only a few hours.

PROS

 This combination potentiates their abilities and effects.
It can give you a boost in physical and mental energy.
 It can enhance your focus and concentration.
It makes for a good addition to pre-workout supplement stacks.
It helps give you a more balanced and positive mood.

 
 

CONS

 Its effects will last only a few hours.
Both these alkaloids have poor bioavailability.
They both have a short half-life.
The stack has an abuse potential.
One can develop a tolerance for this stack.
The daily recommended doses for the Hordenine + PEA stack is set at 30 milligrams of Hordenine, taken with 500 milligrams of PEA, preferably taken earlier in the day. As with other supplements, it will be best to first consult your doctor before starting supplementation with Hordenine + PEA.


Phenylethylamine + Hordenine Benefits

This is where hordenine comes in. Hordenine is an alkaloid extracted from specific type of cactus and in the class of PEA-related chemicals. It also affects levels of norepinephrine within the body and is used as a stand alone supplement for energy, weight loss, body composition, and improved cognitive function.

But when it relates to PEA, the most sought after effects of hordenine are for it acting as an MAO inhibitor. Since MAO quickly breaks down PEA when it’s metabolized, the effects are short lasting. But when combined with the MAOI-like effects of a supplement like hordenine, the positive feelings from PEA can carry on much longer and possibly be amplified.

While the chemical effects of stacking hordenine phenylethylamine are the same, they benefit users in a variety of ways from a planned euphoria during social events on the weekends to energetic, focused workouts. The main uses of PEA/Hordenine are:

Induce a positive mood
General euphoric feelings
Focus and concentration
Energy before a workout
Fat loss (Stimulant)
If you are interested in testing out a combo of hordenine phenylethylamine, especially if you’re mixing bulk powders, you will likely have to experiment to find the dosage that works best for you. Some users like to take 15-30mg of Hordenine with 300-500mg PEA.

As always, it’s best to start on the lower end of the dosage spectrum and slowly work up from there. You can find both PEA and Hordenine at PowderCity.

Sources

http://en.wikipedia.org/wiki/Hordenine

http://xray.bmc.uu.se/Courses/Bke1/1998/Projects/Lovechem/projekt.html

http://en.wikipedia.org/wiki/Phenethylamine

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